Christina Applegateis not shying away from sharing the reality of living with multiple sclerosis.
I lay in bed screaming, Applegate said.
Jamie and I have different everybody has different ways of it showing up.

Christina Applegate in 2020.Jon Kopaloff/Getty
I lay in bed screaming.
Like, the sharp pains, the ache, that squeezing.
There is no current cure.
“Do you feel like that?
She asked, to which Applegate responded, Every single day of my life.
I can’t open bottles now.
Applegate added, Because it’s the beauty of the invisible disease.
Jamie knows that I just lay in bed all the time.
And, before anyone says anything, Applegate clarified that her last comment was made in jest.
I actually don’t lay here and pee in my diaper.
That’s just a joke, she said.
But it’s so freaking painful and so hard and so awkward.
Listen to Applegate reflect on her symptoms in the podcast above.