The actors shared several scenes on the long-running soap during their respective tenures in the early ’80s.

Presley Ann/Getty

Demi MooreandJohn Stamosare bringing the ’80s back.

The superstar actors first appeared together early in their careers onGeneral Hospital.

John Stamos and Demi Moore pose in the photo booth during AARP’s Annual Movies For Grownups Awards at the Beverly Wilshire, A Four Seasons Hotel on February 08, 2025 in Beverly Hills, California.

John Stamos and Demi Moore in 2025.Credit:Presley Ann/Getty

Both Moore and Stamos began their stints onGeneral Hospitalin January 1982 and appeared on the series until April 1984.

Her character was suddenly called out of town in a June 2021 episode and never returned.

But with herGolden Globes win for the film, she saysthe label is finally “irrelevant.”

JOHN STAMOS, DEMI MOORE, GENERAL HOSPITAL - (6/18/82)

John Stamos and Demi Moore on ‘General Hospital’.Erik Hein/Disney General Entertainment Content via Getty