David Yatesis tradingHarry Potterfor painkillers.

And there’s not a spell or potion to be found.

Which is exactly what Yates was looking for.

Pain Hustlers

Emily Blunt and Chris Evans in ‘Pain Hustlers’.Brian Douglas/Netflix

“I spent such a long time on green-screen studios creating these massive environments and these crazy creatures.

So, it was really going back to my roots.

“There wasn’t a visual effect in sight [in those television series].

Pain Hustlers

Andy Garcia and Chris Evans in ‘Pain Hustlers’.Brian Douglas/Netflix

“Emily loved the character and she loved the idea of this story.

(Blunt is also one ofPain Hustlers' executive producers).

“She said, ‘You know what, David?

Pain Hustlers

Catherine O’Hara and Emily Blunt in ‘Pain Hustlers’.Brian Douglas/Netflix

I’m so sick of seeing leading female characters who have to be so honorable and straightforward.’

Guiding Liza through the ins and outs of their job is Evans' Brenner.

“I know he’s been working to subvert that in other roles.

So for me, it was just too much of a delight not to bring him in.

But there’s no fun to be had whereAndy Garcia’s billionaire doctor Jack Neel is concerned.

He developed Lonafan, the pain medication that Zanna is trying to break into the marketplace.

“He’s slightly unpredictable.

And Andy loved doing that.”

“Whenever you cast something, you’re always looking to bring someone in that people don’t expect.

It’s a drama about the opioid crisis.

So the last person you’d expect to cast is Catherine O’Hara.”

Pain Hustlersopens in select theaters on Oct. 20 and will be available to stream Oct. 27 on Netflix.

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