Grey’sAnatomyis officially in its 21st season.

You know what that means - SHOTS!

“I’m ready!

GREY’S ANATOMY - “If Walls Could Talk” ADELAIDE KANE, MIDORI FRANCIS, CHANDRA WILSON, KALI ROCHA, ALEXIS FLOYD , VANDERPUMP RULES – Season:5 – Pictured: (l-r) Lala Kent, James Kennedy, Scheana Marie, Ariana Madix, Tom Sandoval, Lisa Vanderpump, Jax Taylor, Tom Schwartz, Katie Maloney, Stassi Schroeder, Kristen Doute

The casts of ‘Grey’s Anatomy’ and ‘Vanderpump Rules’.Disney/Ser Baffo; Tommy Garcia/Bravo/NBCU Photo Bank/NBCUniversal via Getty

she asks the empty room, confused.

Shay added the caption, “Worlds colliding!!!!!”

Grey’s Anatomyseason 21 premiered on Sept. 26with a bang.

GREY’S ANATOMY episode Baby Can I Hold You

The cast of ‘Grey’s Anatomy’.Anne Marie Fox/Disney