Pamela Hayden also voiced Jimbo Jones, Rod Flanders, and numerous other characters on the show.
Everything is no longer coming up Milhouse.
The episode will premiere this Sunday, Nov. 24, at 8 p.m. on Fox.

Pamela Hayden.Amy Graves/Getty
SimpsonscreatorMatt Groeningexplained Milhouse’s origins in a press release.
“Bart needed someone to talk to in the school cafeteria.
We named him Milhouse because that was the most unfortunate name a kid could have,” he said.

Milhouse on ‘The Simpsons’.FOX
“Pamela gave us tons of laughs with Milhouse, the hapless kid with the biggest nose in Springfield.
She made Milhouse hilarious and real, and we will miss her.”
FOX
Fox said that recasting Milhouse and Hayden’s other characters will start in the near future.
“Here’s to everyone who made this terrific ride I’ve been on possible.
Thanks for 35 years!!
Be well and happy.
My best to you all,” Hayden concluded.
I’ll always have a special place in my heart for that blue-haired 10-year-old boy with glasses."
I love the little guy.
It’s this wonderful analogy for life.
You put your glasses back on, and you go on."