Fotos International/Getty

Noah Wyleis looking back at his and fellowERcostarGeorge Clooneys brief but unforgettable season 1 cameo onFriends.

We were also collegiate back in the old days.

I knew a lot of them before our shows broke," Wyle explained.

Jennifer Aniston and Courteney Cox sit in a hospital room, speaking to guest stars George Clooney and Noah Wyle from ‘ER’ in a still from the television series, ‘Friends,’ circa 1996

Jennifer Aniston, Courteney Cox, George Clooney, and Noah Wyle on season 1 of ‘Friends’.Credit:Fotos International/Getty

“I was friends withMatthew [Perry], I was friends withJennifer [Aniston].

I knew a lot of people that knewDavid [Schwimmer]andLisa [Kudrow].

Wyle explained that he knew Aniston because she had been roommates with an ex-girlfriend of his.

George Clooney and Noah Wyle on ER

George Clooney and Noah Wyle on ‘ER’.Sven Arnstein/NBCU

It was all very social and collegiate.

We all auditioned for the same stuff, he recalled.

And, given the actors all got along so well, a crossover just made sense.

Maggie Wheeler as Janice on Friends

But it seemed totally natural because we were all hanging out anyway, he said.

Chaos, naturally, ensues.

I remember thinking it was almost like a gas that we were doing it.

ER, (aka E.R.), from left, Julianna Margulies, Eriq La Salle, George Clooney, Anthony Edwards, Sherry Stringfield, Noah Wylie, 1994-2009

It was just doing a walk-on.

I didn’t think it had any pressure or attendant pageantry.

That’s how naive I was, he added.

We’re putting them onFriends!

Listen to Wyle discuss the cameo and his thoughts on a second season ofThe Pitt in the podcast above.